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|Title:||Development of granulocytes in haematopoietic tissues of Rhizoprionodon lalandii|
|Authors:||Pacheco, F. J.|
Segreto, R. A.
Egami, Mizue Imoto [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
|Citation:||Journal of Fish Biology. London: Academic Press Ltd Elsevier B.V., v. 61, n. 4, p. 888-898, 2002.|
|Abstract:||Granulocytes of the epigonal and Leydig organs of Rhizoprionodon lalandii were identified and classified into three different cell types, type I and type II eosinophils and neutrophils. the development of these cells in the haematopoietic tissues was dynamic, demonstrated by nuclear immunopositivity for the proliferating cell nuclear antigen (PCNA) proteins and was regulated by various cytokines, including the transforming growth factor beta-1 (TGFbeta(1)). the expression pattern of these cells was heterogeneous among individual cells and TGFbeta(1)-immunostaining was found principally in the cytoplasm of immature granulocytes. the presence of TGFbeta(1) in cells about to divide was demonstrated suggesting that modulation of differentiation and proliferation occurs in the haematopoietic tissues of this species of elasmobranch. (C) 2002 the Fisheries Society of the British Isles. Published by Elsevier B.V. All rights reserved.|
|Appears in Collections:||Em verificação - Geral|
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