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Title: Macrophage signaling by glycosylphosphatidylinositol-anchored mucin-like glycoproteins derived from Trypanosoma cruzi trypomastigotes
Authors: Ropert, C.
Ferreira, LRP
Campos, MAS
Procopio, D. O.
Travassos, L. R.
Ferguson, MAJ
Reis, LFL
Teixeira, M. M.
Almeida, I. C.
Gazzinelli, R. T.
Fiocruz MS
Universidade Federal de Minas Gerais (UFMG)
Ludwig Inst Canc Res
Universidade Federal de São Paulo (UNIFESP)
Univ Dundee
Universidade de São Paulo (USP)
Keywords: Trypanosoma cruzi
GPI anchors
Issue Date: 1-Jul-2002
Publisher: Elsevier B.V.
Citation: Microbes and Infection. Paris Cedex 15: Editions Scientifiques Medicales Elsevier, v. 4, n. 9, p. 1015-1025, 2002.
Abstract: Activation of cells from the innate immune system has an important role in host resistance to early infection with the intracellular protozoan parasite, Trypanosoma cruzi. Here we review the studies that have identified and structurally characterized the glycosylphosphatidylinositol (GPI) anchors, as parasite molecules responsible for the activation of cells from the macrophage lineage. We also cover the studies that have identified the receptor, signaling pathways as well as the array of genes expressed in macrophages that are activated by these glycoconjugates. We discuss the possible-implications of such response on the host resistance to T. cruzi infection and the pathogenesis of Chagas disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
ISSN: 1286-4579
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