Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/26833
Title: Observations on chemical and enzymatic approaches to alpha-2,3-sialylated octyl beta-lactoside
Authors: Turnbull, W. B.
Harrison, J. A.
Kartha, KPR
Schenkman, S.
Field, R. A.
Univ St Andrews
Universidade Federal de São Paulo (UNIFESP)
Keywords: trans-sialidase
synthesis
biotransformations
Issue Date: 15-Apr-2002
Publisher: Elsevier B.V.
Citation: Tetrahedron. Oxford: Pergamon-Elsevier B.V., v. 58, n. 16, p. 3207-3216, 2002.
Abstract: A comparison of chemical and chemo-enzymatic syntheses of alpha-2,3-sialylated octyl lactoside is reported. the chemical approach, starting from lactose and sialic acid, required 14 steps and proceeded in 5% overall yield; poor a-selectivity in the sialylation step necessitated a difficult and low yielding separation of anomers. A chemoenzymatic approach, employing recombinant Trypanosoma cruzi trans-sialidase to effect the key sialylation reaction, required 10 steps and gave a similar overall yield. Whereas the chemo-enzymatic synthesis required only three chromatographic purification steps overall, the chemical synthesis required at least nine. (C) 2002 Elsevier B.V. All rights reserved.
URI: http://repositorio.unifesp.br/handle/11600/26833
ISSN: 0040-4020
Other Identifiers: http://dx.doi.org/10.1016/S0040-4020(02)00265-X
Appears in Collections:Em verificação - Geral

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