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Title: Tonin and kallikrein in the brain of transgenic rat line expressing human tissue kallikrein
Authors: Lomez, ESL
Araujo, R. C.
Bader, Michael [UNIFESP]
Pesquero, João Bosco [UNIFESP]
Pesquero, J. L.
Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Max Delbruck Ctr Mol Med
Keywords: tonin
angiotensin II
Issue Date: 1-Feb-2002
Publisher: Lippincott Williams & Wilkins
Citation: Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 2, p. 229-232, 2002.
Abstract: A transgenic rat line harboring the human tissue kallikrein gene was investigated for expression and activity of tonin and kallikrein in different regions of the brain. the introduction of the transgene into the rat genome produced a significant augmentation of the expression levels and activity of rat tissue kallikrein. the possibility that human kallikrein does not hydrolyze the rat substrate is probably responsible for the augmented expression of the rat enzyme. On the other hand, although expression of tonin was significantly reduced, tonin activity was not altered in most brain structures, except for cerebellum and neurohypophysis.
ISSN: 0194-911X
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Appears in Collections:Em verificação - Geral

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