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Title: Verbal fluency facilitated by the cholinergic blocker, scopolamine
Authors: Pompeia, S.
Rusted, J. M.
Curran, H. V.
Univ Sussex
Universidade Federal de São Paulo (UNIFESP)
Keywords: scopolamine
muscarinic antagonist
verbal fluency
semantic memory
Issue Date: 1-Jan-2002
Publisher: Wiley-Blackwell
Citation: Human Psychopharmacology-clinical and Experimental. Malden: Wiley-Blackwell, v. 17, n. 1, p. 51-59, 2002.
Abstract: This study was designed to explore putative facilitatory effects of low doses of scopolamine (SP) on phonemic (letter) and semantic (category) verbal fluency. A double-blind, parallel-group design was used with 36 subjects who completed a test battery before and 2 h after 0.6 mg or 1.2 mg of SP or placebo. Fluency measures included total number of words generated, clustering (the production of words within semantic or phonemic subcategories) and switching (the ability to shift efficiently to new subcategories). Low doses of scopolamine increased phonemic fluency, as has been shown previously. Semantic fluency was not increased by SP, although subjects treated with 1.2 mg of SP generated higher-frequency words. SP did not affect clustering or switching. It is suggested that phonemic and semantic fluency reflect distinct cognitive processes. Copyright (C) 2002 John Wiley Sons, Ltd.
ISSN: 0885-6222
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Appears in Collections:Em verificação - Geral

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