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|Title:||Isolation and characterisation of genomic and cDNA clones coding for a serine-, alanine-, and proline-rich protein of Trypanosoma cruzi|
|Authors:||Carmo, M. S.|
Cummings, L. M.
Araya, J. E.
Yamauchi, L. M.
Mortara, R. A.
Silveira, J. F. da
Universidade Federal de São Paulo (UNIFESP)
serine-, alanine-, and proline-rich protein (SAP)
surface membrane protein
|Citation:||International Journal for Parasitology. Oxford: Pergamon-Elsevier B.V., v. 31, n. 3, p. 259-264, 2001.|
|Abstract:||We report here the isolation and characterisation of genomic and cDNA clones encoding a Serine-, Alanine-, and Proline-rich protein (SAP) of Trypanosoma cruzi metacyclic trypomastigotes. the deduced peptides translated from these clones were characterised by a high content of residues of alanine, proline, serine, glycine, valine, and threonine distributed in several repeats: P2-4, S2-3, A(2-3), AS, SA, PA, AP, SP, PS, and TP. the repeats are partially homologous to the serine-, alanine-, and proline-containing motifs of Leishmania major and Leishmania mexicana proteophosphoglycans. Genes coding for SAP are part of a polymorphic family whose members are linked to members of gp85/ sialidase and mucin-like gene families. This is consistent with the hypothesis that this genetic organisation could be a means by which T. cruzi co-ordinates the expression of major surface proteins. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier B.V. All rights reserved.|
|Appears in Collections:||Em verificação - Geral|
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