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Title: Treatment of periodic leg movements with a dopaminergic agonist in subjects with total spinal cord lesions
Authors: Mello, Marco Tulio de [UNIFESP]
Poyares, Dalva Lucia [UNIFESP]
Tufik, Sergio [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Keywords: sleep
spinal cord lesion(s)
periodic leg movements (PLM)
restless legs syndrome (RLS)
Issue Date: 1-Sep-1999
Publisher: Stockton Press
Citation: Spinal Cord. Basingstoke: Stockton Press, v. 37, n. 9, p. 634-637, 1999.
Abstract: Objective: To investigate the effect of L-dopa on the PLM/h index of spinal cord injured subjects.Setting: São Paulo, Brazil.Methods: Thirteen male volunteers with spinal cord section between T7-T12, and mean age of 31.6 +/- 8.3 years participated in the study. L-dopa or placebo were administered for 30 days, 1 h before the volunteers went to sleep, in a double blind, crossover design. Polysomnographic recordings were performed on ten occasions: Phase I: Basal night, following an adaptation night at the sleep laboratory; phase 2: after 1, 7, 21 and 30 days of L-dopa administration; phase 3: first night of L-dopa or placebo withdrawal; phase IV: 1, 7, 21 and 30 days after placebo ingestion.Results: the index of PLM/h on the first night of L-dopa or placebo withdrawal (phase III) was lower than on both the basal night and the first night of L-dopa treatment, At the time of polysomnographic analysis, volunteers were divided into two groups: index of PLM/h below five and those whose index was above five. Comparison between L-dopa and placebo treatments revealed that only those volunteers with an index above five revealed a reduction in PLM in L-dopa.Conclusion: These results indicate that despite the spinal cord lesions, L-dopa treatment is capable of minimizing PLM during sleep.
ISSN: 1362-4393
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Appears in Collections:Em verificação - Geral

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