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Title: Organization of telomeric and sub-telomeric regions of chromosomes from the protozoan parasite Trypanosoma cruzi
Authors: Chiurillo, M. A.
Cano, I
Da Silveira, J. F.
Ramirez, J. L.
Cent Univ Venezuela
Inst Estudios Avanzados
Universidade Federal de São Paulo (UNIFESP)
Keywords: Trypanosoma cruzi
telomere organization
surface glycoproteins
Issue Date: 25-May-1999
Publisher: Elsevier B.V.
Citation: Molecular and Biochemical Parasitology. Amsterdam: Elsevier B.V., v. 100, n. 2, p. 173-183, 1999.
Abstract: We present here a characterization of the telomeric and subtelomeric regions of Trypanosoma cruzi chromosomes, using three types of recombinants: cosmids from a genomic library, clones obtained by a vector-adaptor protocol, and a recombinant fragment cloned by a Bal31 trimming protocol. the last nine nucleotides of the T. cruzi overhang are 5'-GGGTTAGGG-3', and there are from 9 to 50 copies of the hexameric repeat 5'-TTAGGG-3', followed by a 189-bp junction sequence common to all recombinants. the subtelomeric region is made of sequences associated with the gp85/sialidase gene family, and/or sequences derived from SIRE, a retrotransposon-like sequence, and also the retrotransposon L1Tc. We discuss the possible implications of this genome organization. (C) 1999 Elsevier Science B.V. All rights reserved.
ISSN: 0166-6851
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