Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/26053
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCasella, AMB
dc.contributor.authorTaba, K. E.
dc.contributor.authorKimura, H.
dc.contributor.authorSpee, C.
dc.contributor.authorCardillo, J. A.
dc.contributor.authorRyan, S. J.
dc.contributor.authorHinton, D. R.
dc.date.accessioned2016-01-24T12:30:47Z-
dc.date.available2016-01-24T12:30:47Z-
dc.date.issued1999-04-01
dc.identifierhttp://dx.doi.org/10.1006/exer.1998.0621
dc.identifier.citationExperimental Eye Research. London: Academic Press Ltd, v. 68, n. 4, p. 423-430, 1999.
dc.identifier.issn0014-4835
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26053-
dc.description.abstractThe pattern of interferon-gamma-induced major histocompatibility complex Class II antigen expression was evaluated on the retinal pigment epithelium. Experiments were performed in vitro using explant cultures of aged and fetal human eyes and in vivo in albino rabbits. the human explants were stimulated with 50 U ml(-1) interferon-gamma for 3 days prior to immunostaining for Class II. the rabbit eyes were subretinally injected in vivo with 50 mu l of interferon-gamma (500 U ml(-1)) and analyzed immunohistochemically 3 days later. A heterogeneous pattern of Class LI expression was present in the interferon-gamma-stimulated retinal pigment epithelial cells, in both the in vivo and the in vitro experiments. in aged human eyes the percent of Class-II positive cells was higher in the periphery than in the posterior pole (macular region) after interferon-gamma stimulation (P < 0.01). No such difference was found in the fetal eyes. These data demonstrate that retinal pigment epithelial cells are heterogeneous in their response to interferon-gamma. the results are supportive of previous studies demonstrating the structural and proliferative heterogeneity of the retinal pigment epithelium. Together, these studies provide support for the possibility of functional retinal pigment epithelial heterogeneity. (C) 1999 Academic Press.en
dc.format.extent423-430
dc.language.isoeng
dc.publisherAcademic Press Ltd
dc.relation.ispartofExperimental Eye Research
dc.rightsAcesso restrito
dc.subjectRPEen
dc.subjectheterogeneityen
dc.subjectMHC class IIen
dc.subjectagingen
dc.subjectPVRen
dc.titleRetinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gammaen
dc.typeArtigo
dc.contributor.institutionUniv So Calif
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv So Calif, Sch Med, Dept Pathol, Los Angeles, CA 90033 USA
dc.description.affiliationUniv So Calif, Sch Med, Doheny Eye Inst, Los Angeles, CA 90033 USA
dc.description.affiliationUniv So Calif, Sch Med, Dept Ophthalmol, Los Angeles, CA 90033 USA
dc.description.affiliationUniv Estadual Londrina, Dept Surg, Londrina, PR USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.identifier.doi10.1006/exer.1998.0621
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000079745000004
Appears in Collections:Em verificação - Geral

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.