Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/25798
Title: Absence of oxidative stress following paradoxical sleep deprivation in rats
Authors: DAlmeida, V
Hipolide, D. C.
Azzalis, L. A.
Lobo, L. L.
Junqueira, VBC
Tufik, Sergio [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Keywords: paradoxical sleep deprivation
oxidative stress
glutathione
antioxidant defense
lipid peroxidation
Issue Date: 10-Oct-1997
Publisher: Elsevier B.V.
Citation: Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 235, n. 1-2, p. 25-28, 1997.
Abstract: Paradoxical sleep deprivation was performed on rats using platform technique to investigate the oxidative process associated with it. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total glutathione (GSH) and malondialdehyde production were measured in brain of rats under control conditions (C) and those on single large platforms (SLP), multiple large platforms (MLP), single small platforms (SSP) and multiple small platforms (MSP) groups. SOD, CAT and GPx brain activity and malondialdehyde production were not modified by any of the procedures. Brain GSH, however, was significantly reduced in both SSP and SLP groups. These results suggest that paradoxical sleep deprivation per se is not associated with oxidative damage. the observed alterations could be attributed to factors such as immobilization and social isolation present in the single platform techniques. (C) 1997 Elsevier Science Ireland Ltd.
URI: http://repositorio.unifesp.br/handle/11600/25798
ISSN: 0304-3940
Other Identifiers: http://dx.doi.org/10.1016/S0304-3940(97)00706-4
Appears in Collections:Em verificação - Geral

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