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|Title:||Effect of alpha-thalassemia and beta-globin gene cluster haplotypes on the hematological and clinical features of sickle-cell anemia in Brazil|
|Authors:||Figueiredo, Maria Stella [UNIFESP]|
Kerbauy, José [UNIFESP]
Goncalves, M. S.
Arruda, V. R.
Sonati, M. F.
Costa, F. F.
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
MED COLL GEORGIA
|Citation:||American Journal of Hematology. New York: Wiley-liss, v. 53, n. 2, p. 72-76, 1996.|
|Abstract:||To compare the features of sickle-cell anemia in Brazil with those in other locales, we studied the effects of the beta-globin-like gene cluster haplotype and alpha-thalassemia upon the clinical and hematological features in 85 patients, the distribution of haplotypes differed from that in the United States and Jamaica, the Central African Republic (CAR) haplotype predominated; 34% of patients were CAR haplotype homozygotes, 45% CAR/Benin homozygotes, and 71% Benin homozygotes. No Senegal haplotype chromosomes were observed, alpha-thalassemia was present in 17.5% of patients, HbF levels were higher in Benin homozygotes, compared with the other two groups (P < 0.05). Nearly half the patients with a CAR haplotype had leg ulcers, compared to 12.5% of the Benin homozygote group; stroke did not occur in alpha-thalassemia carriers, but neither result was statistically significant. As in other studies, our results indicate that the CAR haplotype may be associated with more severe disease. (C) 1996 Wiley-Liss, Inc.|
|Appears in Collections:||Em verificação - Geral|
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