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|Title:||PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS|
|Authors:||Silveira, Vera Lucia Flor [UNIFESP]|
Limaos, E. A.
Nunes, D. W.
Universidade Federal de São Paulo (UNIFESP)
POLYUNSATURATED FATTY ACIDS
|Publisher:||Rapid Science Publishers|
|Citation:||Mediators of Inflammation. London: Rapid Science Publishers, v. 4, n. 5, p. 359-363, 1995.|
|Abstract:||THE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.|
|Appears in Collections:||Em verificação - Geral|
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