Please use this identifier to cite or link to this item: http://repositorio.unifesp.br/handle/11600/25522
Title: PARTICIPATION of the ADRENAL-GLAND in the ANTIINFLAMMATORY EFFECT of POLYUNSATURATED DIETS
Authors: Silveira, Vera Lucia Flor [UNIFESP]
Limaos, E. A.
Nunes, D. W.
Universidade Federal de São Paulo (UNIFESP)
Keywords: CARRAGEENAN EDEMA
CORTICOSTEROIDS
ALPHA(2)-MACROGLOBULIN
POLYUNSATURATED FATTY ACIDS
Issue Date: 1-Sep-1995
Publisher: Rapid Science Publishers
Citation: Mediators of Inflammation. London: Rapid Science Publishers, v. 4, n. 5, p. 359-363, 1995.
Abstract: THE effect of an n-3 (fish) and n-6 (soybean) fatty acid-rich diet on carrageenin paw oedema in rats, and the participation of adrenal gland, corticosterone and alpha(2)-macroglobulin (alpha(2)-M) in this process were studied. A significant inhibition of carrageenin oedema was observed not only in rats fed a diet rich in fish oil but also in the soybean group. alpha(2)-M was not detectable before carrageenin injection, suggesting that this putative anti-inflammatory factor does not participate in the observed anti-inflammatory effect. Corticosterone levels were higher in fat-fed than in control rats, before carrageenin stimulus and adrenalectomy abolished the anti-inflammatory response in fat-fed animals, showing the important role of the adrenocortical hormones in this process.
URI: http://repositorio.unifesp.br/handle/11600/25522
ISSN: 0962-9351
Other Identifiers: http://dx.doi.org/10.1155/S0962935195000585
Appears in Collections:Em verificação - Geral

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