Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/25450
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dc.contributor.authorColombo, A. L.
dc.contributor.authorMcgough, D. A.
dc.contributor.authorRinaldi, M. G.
dc.date.accessioned2016-01-24T11:40:21Z-
dc.date.available2016-01-24T11:40:21Z-
dc.date.issued1994-12-01
dc.identifierhttp://dx.doi.org/10.1007/BF01138472
dc.identifier.citationMycopathologia. Dordrecht: Kluwer Academic Publ, v. 128, n. 3, p. 129-133, 1994.
dc.identifier.issn0301-486X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25450-
dc.description.abstractThere is little information addressing the phenomena of discrepancy between minimal inhibitory concentrations (MIG) and minimal lethal concentrations (MLC) values of amphotericin B (AMB) to clinical isolates of fungi. This study assessed in vitro activity of AMB against 70 clinical isolates of aspergilli: 30 strains of Aspergillus fumigatus, 20 strains of Aspergillus flavus and 20 strains of Aspergillus niger. Susceptibility tests were accomplished using a macro broth dilution procedure, with special emphasis on ascertainment of MLCs. AMB exhibited low MIC values against all clinical isolates. While we did not identify any AMB resistant isolates among 70 Aspergillus spp. studied as judged by MIC levels, analysis of the data demonstrated a clear discrepancy between the MIC and MLC levels of AMB obtained against clinical isolates of Aspergillus spp. the MLC values of AMB were significantly higher than the MIC values with MIC 50 and MIC 90 of 0.29 and 0.5 mu g/ml, respectively, at the second reading time, and MLC 50 and MLC 90 of 2.31 and 9.24 mu g/ml respectively (p < 0.001). Additionally, minimal lethal concentrations in 36/70 (51%) of aspergillal isolates studied produced drug concentrations above those which can usually be sustained in patient plasma or tissue.en
dc.format.extent129-133
dc.language.isoeng
dc.publisherKluwer Academic Publ
dc.relation.ispartofMycopathologia
dc.rightsAcesso restrito
dc.subjectAMPHOTERICIN Ben
dc.subjectASPERGILLUS SPen
dc.subjectSUSCEPTIBILITY TESTINGen
dc.titleDISCREPANCIES BETWEEN MIC and MLC VALUES of AMPHOTERICIN-B AGAINST ISOLATES of ASPERGILLUS SPECIESen
dc.typeArtigo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUNIV TEXAS
dc.description.affiliationESCOLA PAULISTA MED,DEPT MED,DIV INFECT DIS,São Paulo,BRAZIL
dc.description.affiliationUNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,FUNGUS TESTING LAB,SAN ANTONIO,TX 78284
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT MED,DIV INFECT DIS,São Paulo,BRAZIL
dc.identifier.doi10.1007/BF01138472
dc.description.sourceWeb of Science
dc.identifier.wosWOS:A1994QX95200001
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