Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/25450
Title: DISCREPANCIES BETWEEN MIC and MLC VALUES of AMPHOTERICIN-B AGAINST ISOLATES of ASPERGILLUS SPECIES
Authors: Colombo, A. L.
Mcgough, D. A.
Rinaldi, M. G.
Universidade Federal de São Paulo (UNIFESP)
UNIV TEXAS
Keywords: AMPHOTERICIN B
ASPERGILLUS SP
SUSCEPTIBILITY TESTING
Issue Date: 1-Dec-1994
Publisher: Kluwer Academic Publ
Citation: Mycopathologia. Dordrecht: Kluwer Academic Publ, v. 128, n. 3, p. 129-133, 1994.
Abstract: There is little information addressing the phenomena of discrepancy between minimal inhibitory concentrations (MIG) and minimal lethal concentrations (MLC) values of amphotericin B (AMB) to clinical isolates of fungi. This study assessed in vitro activity of AMB against 70 clinical isolates of aspergilli: 30 strains of Aspergillus fumigatus, 20 strains of Aspergillus flavus and 20 strains of Aspergillus niger. Susceptibility tests were accomplished using a macro broth dilution procedure, with special emphasis on ascertainment of MLCs. AMB exhibited low MIC values against all clinical isolates. While we did not identify any AMB resistant isolates among 70 Aspergillus spp. studied as judged by MIC levels, analysis of the data demonstrated a clear discrepancy between the MIC and MLC levels of AMB obtained against clinical isolates of Aspergillus spp. the MLC values of AMB were significantly higher than the MIC values with MIC 50 and MIC 90 of 0.29 and 0.5 mu g/ml, respectively, at the second reading time, and MLC 50 and MLC 90 of 2.31 and 9.24 mu g/ml respectively (p < 0.001). Additionally, minimal lethal concentrations in 36/70 (51%) of aspergillal isolates studied produced drug concentrations above those which can usually be sustained in patient plasma or tissue.
URI: http://repositorio.unifesp.br/handle/11600/25450
ISSN: 0301-486X
Other Identifiers: http://dx.doi.org/10.1007/BF01138472
Appears in Collections:Em verificação - Geral

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