Please use this identifier to cite or link to this item: https://repositorio.unifesp.br/handle/11600/25402
Title: A CONTROLLED TRIAL of PULSE CYCLOPHOSPHAMIDE VERSUS PULSE METHYLPREDNISOLONE in SEVERE LUPUS NEPHRITIS
Authors: Sesso, R.
Monteiro, M.
Sato, E.
Kirsztajn, G.
Silva, L.
Ajzen, H.
Universidade Federal de São Paulo (UNIFESP)
Keywords: SYSTEMIC
LUPUS
ERYTHEMATOSUS
NEPHRITIS
CYCLOPHOSPHAMIDE
METHYLPREDNISOLONE
PULSE
TREATMENT
Issue Date: 1-Apr-1994
Publisher: Stockton Press
Citation: Lupus. Basingstoke: Stockton Press, v. 3, n. 2, p. 107-112, 1994.
Abstract: We carried out a prospective randomized trial comparing pulse cyclophosphamide and pulse methylprednisolone in 29 patients with severe lupus nephritis in activity. Patients were assigned to one of two regimens: monthly pulse cyclophosphamide (0.5-1.0 g/m2 body surface area) for 4 months, followed by bimonthly doses for 4 months and quarterly doses for 6 months (14 patients) or pulse methylprednisolone (10-20 mg/kg weight) initially for 3 consecutive days and thereafter in the same intervals as the alternative regimen (15 patients). the mean follow-up was 15 months. Two patients in the cyclophosphamide group and three in the methylprednisolone group died. Renal failure (doubling of serum creatinine) developed in four patients in the cyclophosphamide group compared with five patients in the methylprednisolone group. Cumulative probability of not doubling serum creatinine was similar for cyclophosphamide and methylprednisolone groups (0.66 vs 0.69, respectively, P > 0.20, after 18 months). Cumulative probability of survival without renal failure was also not significantly different (0.61 and 0.63, respectively, P > 0.20, after 18 months). These results suggest that pulse cyclophosphamide is as effective as pulse methylprednisolone in preserving renal function in patients with severe lupus nephritis.
URI: http://repositorio.unifesp.br/handle/11600/25402
ISSN: 0961-2033
Other Identifiers: http://dx.doi.org/10.1177/096120339400300209
Appears in Collections:Em verificação - Geral

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