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Title: Demographic and anthropometrical analysis and genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil
Authors: Focaccia, R.
Baraldo, D.c.m.
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Martinelli, A.l.c.
Carrilho, F.j.
Gonçales Junior, Fernando Lopes
Pedroso, M.l.a.
Coelho, H.s.m.
Lacerda, M.a.
Brandão, C.e.
Mattos, A.a.
Lira, L.g.c.
Zamin Jr., I.
Pinheiro, J.o.p.
Tovo, C.v.
Both, C.t.
Soares, J.a.s.
Dittrich, S.
Emílio Ribas Institute
Universidade Federal de São Paulo (UNIFESP)
São Paulo University Medical School of Ribeirão Preto
São Paulo University School of Medicine
Universidade Estadual de Campinas (UNICAMP)
Federal University of Paraná
Secretary of State of Paraná CRE Metropolitan
Federal University of Rio de Janeiro
Private Institution
UNIRIO Graffée Guinle Universitary Hospital
Santa Casa de Misericórdia Gastroenterology Service
Federal University of Bahia
Keywords: HCV
chronic hepatitis C
body weight
Issue Date: 1-Oct-2004
Publisher: Brazilian Society of Infectious Diseases
Citation: Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 8, n. 5, p. 348-355, 2004.
Abstract: Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients (80%). The analysis of HCV-infecting strains showed a predominance of genotype 1 (64%) over genotypes 2 and 3. The patients' mean weight was 70.6 kg, and 65% of the patients weighed less than 77kg. Overweight and obesity were observed in 37.8% and 13.6% of the patients, respectively. Since a body weight of 75 kg or less has been considered an independent factor that significantly increases the odds of achieving a sustained virological response, the Brazilian population seems to have a more favorable body weight profile to achieve a sustained response than the American and European populations. The finding that 65% of chronic hepatitis C patients have a body weight of 77 kg or less may have a positive pharmacoeconomic impact on the treatment of genotype 1 HCV patients with weight-based doses of peginterferon.
ISSN: 1413-8670
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