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dc.contributor.advisorKamimura, Maria Ayako [UNIFESP]
dc.contributor.authorFiguiredo-Dias, Vilani [UNIFESP]
dc.identifier.citationFIGUIREDO-DIAS, Vilani. Fatores associados à hipovitaminose D na doença renal crônica. 2011. 103 f. Dissertação (Mestrado em Ciências) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2011.
dc.description.abstractBackground: Hypovitaminosis D is highly prevalent among chronic kidney disease patients and it has been associated with worse outcome even in the earlier stages of the disease. Objective: This study aimed to investigate the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Design: This cross-sectional study included 120 chronic kidney disease patients on stages 2 to 5 (62% male, age 55.4±11.3yr, estimated glomerular filtration rate 35.1±15ml/min, body mass index (BMI) 27.1±5.2kg/m2, 31% diabetics). Serum 25-hydroxivitamin D was measured by chemiluminescence. Subjective global assessment, total body fat (dual-energy X-ray absorptiometry), visceral and subcutaneous abdominal fat (computed tomography) and several laboratory parameters were assessed. Results: Insufficiency of 25-hydroxivitamin D (15-30ng/ml) was observed in 55% of the patients and deficiency (<15ng/ml) in 20%. Patients with diabetes, BMI ≥30kg/m2, and who had the blood collection during the winter or spring had lower 25-hydroxivitamin D levels. Serum 25-hydroxivitamin D correlated inversely with parathyroid hormone, proteinuria, insulin resistance, leptin, and subcutaneous abdominal fat. The risk factors for hypovitaminosis D were diabetes (odds ratio 3.8; 95% CI 1.2-11.7; P=0.022) and BMI ≥30kg/m2 (odds ratio 4.3; 95% CI 1.2-15.3; P=0.018). In the logistic regression analysis adjusting for gender, skin color and season of the year, diabetes and BMI ≥30kg/m2 were independently associated with hypovitaminosis D. Conclusions: Diabetes and obesity were the risk factors for hypovitaminosis D in nondialyzed chronic kidney disease patients. Effective interventional protocols of vitamin D supplementation taking into account these risk factors are warranted for this population.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação Oswaldo Ramos
dc.format.extent103 f.
dc.publisherUniversidade Federal de São Paulo (UNIFESP)
dc.rightsAcesso aberto
dc.subjectDeficiência de Vitaminaspt
dc.subjectDeficiência de Vitamina Dpt
dc.subjectDiabetes Mellituspt
dc.subjectDoença Crônicapt
dc.subjectHypovitaminosis Den
dc.subject25-hydroxivitamin Den
dc.subjectChronic kidney disease.en
dc.titleFatores associados à hipovitaminose D na doença renal crônicapt
dc.title.alternativeFactors associated with vitamin D deficiency in chronic kidney diseaseen
dc.typeDissertação de mestrado
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.sourceBV UNIFESP: Teses e dissertações
unifesp.campusSão Paulo, Escola Paulista de Medicina (EPM)pt
unifesp.graduateProgramNutrição - São Paulo
Appears in Collections:Em verificação - Dissertações e teses

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