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Title: Cardiovascular control in experimental diabetes
Authors: De Angelis, Katia
Schaan, Beatriz D'Agord
Maeda, C.y.
Dal Lago, Pedro
Wichi, Rogerio Brandao [UNIFESP]
Irigoyen, Maria Claudia [UNIFESP]
Universidade de Santo Amaro UNIPESQ Laboratório de Cardiovascular
Universidade Federal do Rio Grande do Sul Instituto de Ciências Básicas da Saúde Departamento de Fisiologia
Instituto de Cardiologia do Rio Grande do Sul Fundação Universitária de Cardiologia
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Pontifícia Universidade Católica do Rio Grande do Sul FAENFI Curso de Fisioterapia
Keywords: Experimental diabetes
Arterial pressure
Autonomic control
Cardiopulmonary reflex
Exercise training
Issue Date: 1-Sep-2002
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 9, p. 1091-1100, 2002.
Abstract: Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes.
ISSN: 0100-879X
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