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Title: Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells
Authors: Nader, Helena Bonciani [UNIFESP]
Pinhal, Maria Aparecida da Silva [UNIFESP]
Baú, Elaine Cristina [UNIFESP]
Castro, Ricardo Augusto Braga de [UNIFESP]
Medeiros, Guilherme Fulgencio [UNIFESP]
Chavante, Suely Ferreira [UNIFESP]
Leite, Edda Lisboa [UNIFESP]
Trindade, Edvaldo da Silva [UNIFESP]
Shinjo, Samuel Katsuyuki [UNIFESP]
Rocha, Hugo Alexandre Oliveira [UNIFESP]
Tersariol, Ivarne Luis dos Santos [UNIFESP]
Mendes, Aline [UNIFESP]
Dietrich, Carl Peter [UNIFESP]
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio Grande do Norte Departamento de Oceanografia
Universidade Federal do Rio Grande do Norte Departamento de Bioquímica
Universidade de Mogi das Cruzes Centro de Investigação Bioquímica
Keywords: heparin, anticlotting activity
heparan sulfate, antithrombotic activity
low molecular weight heparins, preparation and antithrombotic activity
antithrombotic agents, development for clinical use
crustacean heparin-like compounds, antithrombotic activity
antithrombotic agents
vascular endothelial cells
Issue Date: 1-Jun-2001
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 6, p. 699-709, 2001.
Abstract: The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
ISSN: 0100-879X
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