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Title: The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis
Authors: Andreatini, R.
Blanchard, C.
Blanchard, R.
Brandão, M.l.
Carobrez, A.p.
Griebel, G.
Guimarães, F.s.
Handley, S.l.
Jenck, F.
Leite, Jose Roberto [UNIFESP]
Rodgers, J.
Schenberg, L.c.
Da Cunha, C.
Graeff, F.g.
Universidade Federal do Paraná Departamento de Farmacologia Laboratório de Fisiologia e Farmacologia do Sistema Nervoso Central
University of Hawaii Department of Neurobiology
University of Hawaii Department of Psychology
Universidade de São Paulo (USP)
Universidade Federal de Santa Catarina Departamento de Farmacologia
Central Nervous System Research Department Sanofi Synthelabo
Aston University Institute of Pharmaceutical Sciences
Hoffmann-La Roche Ltd.
Universidade Federal de São Paulo (UNIFESP)
University of Leeds Department of Psychology Ethopharmacology Laboratory
Universidade Federal do Espírito Santo Centro de Biomedicina Departamento de Ciências Fisiológicas
Keywords: panic
periaqueductal gray matter
animal models
Issue Date: 1-Feb-2001
Publisher: Associação Brasileira de Divulgação Científica
Citation: Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 2, p. 145-154, 2001.
Abstract: This article is a transcription of an electronic symposium sponsored by the Brazilian Society of Neuroscience and Behavior (SBNeC). Invited researchers from the European Union, North America and Brazil discussed two issues on anxiety, namely whether panic is a very intense anxiety or something else, and what aspects of clinical anxiety are reproduced by animal models. Concerning the first issue, most participants agreed that generalized anxiety and panic disorder are different on the basis of clinical manifestations, drug response and animal models. Also, underlying brain structures, neurotransmitter modulation and hormonal changes seem to involve important differences. It is also common knowledge that existing animal models generate different types of fear/anxiety. A challenge for future research is to establish a good correlation between animal models and nosological classification.
ISSN: 0100-879X
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