Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant

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dc.contributor.author Muccioli, Cristina [UNIFESP]
dc.contributor.author Belfort, Rubens Junior [UNIFESP]
dc.date.accessioned 2015-06-14T13:25:05Z
dc.date.available 2015-06-14T13:25:05Z
dc.date.issued 2000-07-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2000000700008
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 7, p. 779-789, 2000.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/996
dc.description.abstract The objective of this prospective study was to evaluate the efficacy and complications of the use of an intraocular sustained-release ganciclovir implant for the treatment of active cytomegalovirus (CMV) retinitis in AIDS patients. Thirty-nine eyes of 26 patients were submitted to ocular surgery. All patients underwent complete ocular examination before and after surgery. The surgical procedure was always done under local anesthesia using the same technique. The mean time for the surgical procedure was 20 min (range, 15 to 30 min). The average follow-up period was 3.7 months. Of all patient, only 4 presented recurrence of retinitis after 8, 8, 9 and 2 months, respectively. Three of them received a successful second implant. All 39 eyes of the 26 patients presented healing of retinitis as shown by clinical improvement evaluated by indirect binocular ophthalmoscopy and retinography. Retinitis healed within a period of 4 to 6 weeks in all patients, with clinical regression signs from the third week on. Six (15.4%) eyes developed retinal detachment. None of the patients developed CMV retinitis in the contralateral eye. The intraocular implant proved to be effective in controlling the progression of retinitis for a period of up to 8 months even in patients for whom systemic therapy with either ganciclovir or foscarnet or both had failed. The intraocular sustained-release ganciclovir implant proved to be a safe new procedure for the treatment of CMV retinitis, avoiding the systemic side effects caused by the intravenous medications and improving the quality of life of the patients. en
dc.format.extent 779-789
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject cytomegalovirus en
dc.subject retinitis en
dc.subject intraocular inflammation en
dc.subject AIDS en
dc.subject uveitis en
dc.title Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifesp UNIFESP
dc.identifier.file S0100-879X2000000700008.pdf
dc.identifier.scielo S0100-879X2000000700008
dc.identifier.doi 10.1590/S0100-879X2000000700008
dc.description.source SciELO
dc.identifier.wos WOS:000088236100008



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