Prostate-Specific Antigen testing in men between 40 and 70 years in Brazil: database from a check-up program

Prostate-Specific Antigen testing in men between 40 and 70 years in Brazil: database from a check-up program

Autor Zambon, João Paulo Autor UNIFESP Google Scholar
Almeida, Fernando G. Google Scholar
Conceição, Raquel Dilguerian O Google Scholar
Tabone, Viviane Arevalo Google Scholar
Kashiwagi, Nea Miwa Google Scholar
Ross, Christina L. Google Scholar
Carvalho, José Antônio Maluf De Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Hospital Israelita Albert Einstein
Wake Forest University
Resumo Objectives To evaluate the PSA in a large population of Brazilian men undergone to check up, and correlate the PSA cutoffs with prostate size and urinary symptoms. Materials and Methods This is a cross sectional study performed with men between 40 and 70 years undergone to check-up. All men were undergone to urological evaluation, digital rectal examination, prostate-specific antigen, and ultrasonography The exclusion criteria were men who used testosterone in the last six months, or who were using 5 alpha-reductase inhibitors. Results A total of 5015 men with an average age of 49.0 years completed the study. Most men were white and asymptomatic. The PSA in the three different aging groups were 0.9 ± 0.7ng/dL for men between 40 and 50; 1.2 ± 0.5ng/dL for men between 50 and 60; and 1.7 ± 1.5ng/dL for men greater than 60 years (p=0.001). A total of 192 men had PSA between 2.5 and 4ng/ml. From these men 130 were undergone to prostate biopsy. The predictive positive value of biopsy was 25% (32/130). In the same way, 100 patients had PSA >4ng/mL. From these men, 80 were undergone to prostate biopsy. In this group, the predictive positive value of biopsy was 40% (32/100). The Gleason score was 6 in 19 men (60%), 7 in 10 men (31%) and 8 in 3 men (9%). Conclusions The PSA level of Brazilian men undergone to check up was low. There was a positive correlation with aging, IPSS and prostate size.
Palavra-chave screening
prostate cancer
PSA
IPSS
check up
prostate size
Idioma Inglês
Data de publicação 2014-12-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 40, n. 6, p. 745-752, 2014.
ISSN 1677-5538 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira de Urologia
Extensão 745-752
Fonte http://dx.doi.org/10.1590/S1677-5538.IBJU.2014.06.05
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000348607500005
SciELO S1677-55382014000600745 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8768

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