Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment

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dc.contributor.author Cividanes, Giuliana C.
dc.contributor.author Mello, Andrea Feijó
dc.contributor.author Sallum, Juliana M.
dc.contributor.author Fossaluza, Victor
dc.contributor.author Medeiros, Marcio de
dc.contributor.author Maciel, Mariana R.
dc.contributor.author Cavalcante-Nóbrega, Luciana Porto [UNIFESP]
dc.contributor.author Mari, Jair de Jesus [UNIFESP]
dc.contributor.author Mello, Marcelo Feijó de [UNIFESP]
dc.contributor.author Valentte, Nina L.
dc.date.accessioned 2015-06-14T13:47:23Z
dc.date.available 2015-06-14T13:47:23Z
dc.date.issued 2014-12-01
dc.identifier http://dx.doi.org/10.1590/1516-4446-2013-1150
dc.identifier.citation Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.
dc.identifier.issn 1516-4446
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/8677
dc.description.abstract Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk. en
dc.format.extent 277-284
dc.language.iso eng
dc.publisher Associação Brasileira de Psiquiatria - ABP
dc.relation.ispartof Revista Brasileira de Psiquiatria
dc.rights Acesso aberto
dc.subject Serotonin transporter polymorphism en
dc.subject child maltreatment en
dc.subject child labor en
dc.subject street children en
dc.title Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Ocular Genetic Institute
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution King's College London Institute of Psychiatry Health Service and Population Research Department
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Department of Psychiatry
dc.description.affiliation Ocular Genetic Institute
dc.description.affiliation College of Public Health, USP
dc.description.affiliation Universidade de São Paulo (USP) Institute of Mathematics and Statistics
dc.description.affiliation King's College London Institute of Psychiatry Health Service and Population Research Department
dc.description.affiliationUnifesp UNIFESP, Department of Psychiatry
dc.identifier.file S1516-44462014000500277.pdf
dc.identifier.scielo S1516-44462014000500277
dc.identifier.doi 10.1590/1516-4446-2013-1150
dc.description.source SciELO



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