Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment

Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment

Author Cividanes, Giuliana C. Google Scholar
Mello, Andrea Feijó Google Scholar
Sallum, Juliana M. Google Scholar
Fossaluza, Victor Google Scholar
Medeiros, Marcio de Google Scholar
Maciel, Mariana R. Google Scholar
Cavalcante-Nóbrega, Luciana Porto Autor UNIFESP Google Scholar
Mari, Jair de Jesus Autor UNIFESP Google Scholar
Mello, Marcelo Feijó de Autor UNIFESP Google Scholar
Valentte, Nina L. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ocular Genetic Institute
Universidade de São Paulo (USP)
King's College London Institute of Psychiatry Health Service and Population Research Department
Abstract Objective: To ascertain whether genetic variations in the serotonin transporter gene (5-HTTLPR 44-bp insertion/deletion polymorphism) influence an increase in depressive and anxiety symptoms in children and adolescents exposed to high levels of violence. Methods: Saliva samples were collected from a group of children who were working on the streets and from their siblings who did not work on the streets. DNA was extracted from the saliva samples and analyzed for 5-HTTLPR polymorphism genotypes. Results: One hundred and seventy-seven children between the ages of 7 and 14 years were analyzed (114 child workers and 63 siblings). Data on socioeconomic conditions, mental symptoms, and presence and severity of maltreatment and urban violence were collected using a sociodemographic inventory and clinical instruments. There was no positive correlation between the 5-HTTLPR polymorphism and presence of mental symptoms in our sample, although the children were exposed to high levels of abuse, neglect, and urban violence. Conclusions: Despite previous studies that associated adult psychiatric disorders with the 5-HTTLPR polymorphism and a history of childhood maltreatment, no such association was found in this sample of children at risk.
Keywords Serotonin transporter polymorphism
child maltreatment
child labor
street children
Language English
Date 2014-12-01
Published in Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 4, p. 277-284, 2014.
ISSN 1516-4446 (Sherpa/Romeo)
Publisher Associação Brasileira de Psiquiatria - ABP
Extent 277-284
Origin http://dx.doi.org/10.1590/1516-4446-2013-1150
Access rights Open access Open Access
Type Article
SciELO ID S1516-44462014000500277 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8677

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