Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus

Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus

Author Vieira, Michele Juliane Autor UNIFESP Google Scholar
Perosa, Sandra Regina Autor UNIFESP Google Scholar
Argañaraz, Gustavo Adolfo Autor UNIFESP Google Scholar
Silva Junior, Jose Antonio Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein Neurofisiologia Clínica
Universidade de Brasília Faculdade de Ciências da Saúde Laboratório de Patologia Molecular
Universidade Nove de Julho Departamento de Educação Física Programa de Pós-Graduação em Ciências da Reabilitação
Abstract OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules.METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry.RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin.CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus.
Keywords Indomethacin
Inflammatory Mediators
Epilepsy
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
Institutos Nacionais de Ciencia e Tecnologia (INCT)
Programa de Apoio a Nucleos de Excelencia (PRONEX)
Date 2014-09-01
Published in Clinics. Faculdade de Medicina / USP, v. 69, n. 9, p. 621-626, 2014.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
1980-5322 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 621-626
Origin http://dx.doi.org/10.6061/clinics/2014(09)08
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000343983100008
SciELO ID S1807-59322014000900621 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8599

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