Association between age at diagnosis and degree of liver injury in hepatitis C

Association between age at diagnosis and degree of liver injury in hepatitis C

Autor Oliveira, Ana Claudia de Autor UNIFESP Google Scholar
Bortotti, Ana Clara Google Scholar
Nunes, Nathália Neves Google Scholar
Bacha, Ibrahin Ahmad Hussein El Autor UNIFESP Google Scholar
Parise, Edison Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de São Carlos (UFSCar) Department of Medicine
Resumo Introduction: A population-based survey conducted in Brazilian capital cities found that only 16% of the population had ever been tested for hepatitis C. These data suggest that much of the Brazilian population with HCV infection remains undiagnosed. The distribution of age ranges at diagnosis and its association with the degree of hepatitis C are still unknown in Brazilian patients. Material and methods: Patients with HCV infection, diagnosed by HCV RNA (Amplicor-HCV, Roche), were included in the study. Patients with HBV or HIV coinfection, autoimmune diseases, or alcohol intake > 20 g/day were excluded. HCV genotyping was performed by sequence analysis, and viral load by quantitative RT-PCR (Amplicor, Roche). The METAVIR classification was used to assess structural liver injury. The Chi-square (χ2) test and student's t-test were used for between-group comparisons. Spearman's rank correlation coefficient were used for analysing the correlation between parameters. Results: A total of 525 charts were reviewed. Of the patients included, 49.5% were male, only 10% of the patients were aged less than 30 years; peak prevalence of HCV infection occurred in the 51-to-60 years age range. Genotype 1 accounted for 65.4% of the cases. Information on HCV subtype was obtained in 227 patients; 105 had subtype 1a and 122 had 1b. According to the degree of structural liver injury, 8.3% had F0, 23.4% F1, 19.8% F2, 11.9% F3, and 36.5% F4. Age at diagnosis of hepatitis correlated significantly with fibrosis (rs = 0.307, p < 0.001). The degree of fibrosis increased with advancing age. Only age at diagnosis and fasting blood glucose were independently associated with disease stage. Those patients with subtype 1a had higher prevalence of F2–F4 than those with subtype 1b. Conclusion: In Brazil, diagnosis of hepatitis C is more commonly established in older patients (age 45–60 years) with more advanced disease. Reassessment of strategies for hepatitis C diagnosis in the country is required.
Palavra-chave Chronic hepatitis C
Age at diagnosis
Hepatic fibrosis
Idioma Inglês
Data de publicação 2014-09-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 18, n. 5, p. 507-511, 2014.
ISSN 1413-8670 (Sherpa/Romeo, fator de impacto)
Publicador Brazilian Society of Infectious Diseases
Extensão 507-511
Fonte http://dx.doi.org/10.1016/j.bjid.2014.04.003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000346072300008
WOS:000346072300008
SciELO S1413-86702014000500507 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8580

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