Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus

Imbalanced expression of functional surface molecules in regulatory and effector T cells in systemic lupus erythematosus

Autor Mesquita Júnior, Danilo Autor UNIFESP Google Scholar
Cruvinel, Wilson de Melo Autor UNIFESP Google Scholar
Araujo, J.a.p. Google Scholar
Carvalho, Karina Inacio Autor UNIFESP Google Scholar
Kallas, Esper Georges Autor UNIFESP Google Scholar
Andrade, Luiz Eduardo Coelho Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Católica de Goiás Departamento de Biomedicina
Universidade de São Paulo (USP)
Resumo Regulatory T (TREG) cells play an important role in maintaining immune tolerance and avoiding autoimmunity. We analyzed the expression of membrane molecules in TREG and effector T cells in systemic lupus erythematosus (SLE). TREG and effector T cells were analyzed for the expression of CTLA-4, PD1, CD28, CD95, GITR, HLA-DR, OX40, CD40L, and CD45RO in 26 patients with active disease, 31 with inactive disease, and 26 healthy controls. TREG cells were defined as CD25+/highCD127Ø/lowFoxP3+, and effector T cells were defined as CD25+CD127+FoxP3Ø. The ratio of TREG to effector T cells expressing GITR, PD1, HLA-DR, OX40, CD40L, and CD45RO was determined in the three groups. The frequency of TREG cells was similar in patients with SLE and controls. However, SLE patients had a decreased frequency of CTLA-4+TREG and CD28+TREG cells and an increased frequency of CD40L+TREG cells. There was a decrease in the TREG/effector-T ratio for GITR+, HLA-DR+, OX40+, and CD45RO+ cells, and an increased ratio of TREG/effector-T CD40L+ cells in patients with SLE. In addition, CD40L+TREG cell frequency correlated with the SLE disease activity index (P=0.0163). In conclusion, our findings showed several abnormalities in the expression of functionally critical surface molecules in TREG and effector T cells in SLE that may be relevant to the pathogenesis of this disease.
Palavra-chave Systemic lupus erythematosus
T lymphocytes
Regulatory T cells
Effector T cells
Idioma Inglês
Data de publicação 2014-08-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 47, n. 8, p. 662-669, 2014.
ISSN 0100-879X (Sherpa/Romeo)
Publicador Associação Brasileira de Divulgação Científica
Extensão 662-669
Fonte http://dx.doi.org/10.1590/1414-431X20143483
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S0100-879X2014000800662 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8521

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