Comparison among the BED capture enzyme immunoassay test and AxSYM avidity index assay for determining recent HIV infection and incidence in two Voluntary Counselling and Testing Centres in Northeast Brazil

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dc.contributor.author Salustiano, Daniela Medeiros
dc.contributor.author Lima, Kledoaldo Oliveira de
dc.contributor.author Cavalcanti, Ana Maria Salustiano
dc.contributor.author Diaz, Ricardo Sobhie [UNIFESP]
dc.contributor.author Lacerda, Heloisa Ramos
dc.date.accessioned 2015-06-14T13:47:12Z
dc.date.available 2015-06-14T13:47:12Z
dc.date.issued 2014-07-01
dc.identifier http://dx.doi.org/10.1016/j.bjid.2014.03.001
dc.identifier.citation Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 18, n. 4, p. 449-453, 2014.
dc.identifier.issn 1413-8670
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/8492
dc.description.abstract The aims of this study were to compare the automated AxSYM avidity assay index with the BED capture enzyme immunoassay test and to calculate the HIV-1 incidence using the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms within a population seeking the Voluntary Counselling and Testing Centres in two municipalities in the Metropolitan Region of Recife, Northeast of Brazil. An analysis was conducted in 365 samples that tested positive for HIV infection from frozen serum collected during the period 2006-2009. There was a similar proportion of males and females; most patients were heterosexual (86%) with a median age of 29 years. Of the 365 samples, 102 (28%) and 66 (18.1%) were identified as recent infections by BED capture enzyme immunoassay and AxSYM avidity assay index, respectively. The HIV-1 total incidence in the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms were: 0.79 (95% CI: 0.60-0.98) and 0.34 (95% CI: -0.04 to 0.72), respectively. Incidence was higher among men. There was good agreement between the tests, with a kappa of 0.654 and a specificity of 95.8%. AxSYM avidity assay index may be helpful in improving the quality of the estimates of recent HIV infection and incidence, particularly when used in a combined algorithm with BED capture enzyme immunoassay. en
dc.description.sponsorship Programa Nacional de Cooperação Acadêmica
dc.description.sponsorship Ação Novas Fronteiras (Procad - NF)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 449-453
dc.language.iso eng
dc.publisher Brazilian Society of Infectious Diseases
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights Acesso aberto
dc.subject HIV en
dc.subject Recent infection en
dc.subject Avidity index assay en
dc.subject BED-CEIA en
dc.title Comparison among the BED capture enzyme immunoassay test and AxSYM avidity index assay for determining recent HIV infection and incidence in two Voluntary Counselling and Testing Centres in Northeast Brazil en
dc.type Artigo
dc.contributor.institution The Herbert de Souza Counselling and Testing Centre
dc.contributor.institution Universidade Federal de Pernambuco
dc.contributor.institution The Paulista Counselling and Testing Centre
dc.contributor.institution Laboratório Central de Pernambuco Department of Virology
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation The Herbert de Souza Counselling and Testing Centre
dc.description.affiliation Universidade Federal de Pernambuco
dc.description.affiliation The Paulista Counselling and Testing Centre
dc.description.affiliation Laboratório Central de Pernambuco Department of Virology
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifesp UNIFESP
dc.identifier.file S1413-86702014000400449.pdf
dc.identifier.scielo S1413-86702014000400449
dc.identifier.doi 10.1016/j.bjid.2014.03.001
dc.description.source SciELO
dc.identifier.wos WOS:000341171200015



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