Fungemia caused by Candida species in a children's public hospital in the city of São Paulo , Brazil: study in the period 2007-2010

Fungemia caused by Candida species in a children's public hospital in the city of São Paulo , Brazil: study in the period 2007-2010

Alternative title Fungemia por espécies de Candida em Hospital Pediátrico da cidade de São Paulo, Brasil: estudo no período de 2007 a 2010
Author Oliveira, Vanessa Kummer Perinazzo Google Scholar
Ruiz, Luciana da Silva Google Scholar
Oliveira, Nélio Alessandro Jesus Google Scholar
Moreira, Débora Google Scholar
Hahn, Rosane Christine Google Scholar
Melo, Analy Salles de Azevedo Autor UNIFESP Google Scholar
Nishikaku, Angela Satie Google Scholar
Paula, Claudete Rodrigues Google Scholar
Institution University of São Paulo Institute of Biomedical Science II Department of Microbiology
University of Minnesota Dept. of Medicine Lillehei Heart Institute
Federal University of Mato Grosso Division of Infectious and Tropical Diseases
Universidade Federal de São Paulo (UNIFESP)
University of São Paulo School of Dentistry Department de Stomatology
Abstract Candidemia remains a major cause of morbidity and mortality in the health care environment. The epidemiology of Candida infection is changing, mainly in relation to the number of episodes caused by species C. non-albicans. The overall objective of this study was to evaluate the frequency of yeasts of the genus Candida, in a four-year period, isolated from blood of pediatric patients hospitalized in a public hospital of the city of São Paulo, Brazil. In this period, yeasts from blood of 104 patients were isolated and, the identified species of Candida by phenotypic and genotypic methods were: C. albicans (39/104), C. tropicalis (25/104), C. parapsilosis (23/104), Pichia anomala (6/104), C. guilliermondii (5/104), C. krusei (3/104), C. glabrata (2/104) and C. pararugosa (1/104). During the period of the study, a higher frequency of isolates of C. non-albicans (63.55%) (p = 0.0286) was verified. In this study we verified the increase of the non-albicans species throughout the years (mainly in 2009 and 2010). Thus, considering the peculiarities presented by Candida species, a correct identification of species is recommended to lead to a faster diagnosis and an efficient treatment.

Candidemia permance como a maior causa de morbidade e mortalidade em ambiente hospitalar. A epidemiologia de infecções por Candida vem se alterando, principalmente em relação ao número de episódios causados por espécies não-albicans. Este estudo teve como objetivo avaliar a frequência, em um período de quatro anos, de leveduras do gênero Candida isoladas de sangue de pacientes pediátricos internados em hospital público da cidade de São Paulo, Brasil. Neste período foram isoladas leveduras de sangue de 104 pacientes, e as espécies de Candida identificadas, por métodos fenotípicos e genotípicos, foram: C. albicans (39/104), C. tropicalis (25/104), C. parapsilosis (23/104), Pichia anomala (6/104), C. guilliermondii (5/104), C. krusei (3/104), C. glabrata (2/104) e C. pararugosa (1/104). Em todo período do estudo foi observada maior frequência de isolamento de C. não-albicans (63,55%) (p = 0,0286). Neste estudo verificou-se aumento das espécies não-albicans ao longo dos anos (principalmente em 2009 e 2010), assim, ressalta-se que correta identificação em nível de espécie é recomendável, para que isso acarrete diagnóstico rápido e tratamento eficaz.
Keywords Candida
Candidemia
Pediatric
Language English
Date 2014-07-01
Published in Revista do Instituto de Medicina Tropical de São Paulo. Instituto de Medicina Tropical, v. 56, n. 4, p. 301-305, 2014.
ISSN 0036-4665 (Sherpa/Romeo)
Publisher Instituto de Medicina Tropical
Extent 301-305
Origin http://dx.doi.org/10.1590/S0036-46652014000400006
Access rights Open access Open Access
Type Article
SciELO ID S0036-46652014000400301 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8486

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