Acute pancreatitis associated with boceprevir: a case report

Acute pancreatitis associated with boceprevir: a case report

Author Bilar, Juliana Miguel Autor UNIFESP Google Scholar
Carvalho-Filho, Roberto José de Autor UNIFESP Google Scholar
Mota, Carolina Frade Magalhães Girardin Pimentel Autor UNIFESP Google Scholar
Pereira, Patrícia da Silva Fucuta Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Approximately 170 million people are infected with hepatitis C, and the sustained virological response rate to treatment with pegylated interferon and ribavirin is 30-50%. In an attempt to improve the chances of cure, boceprevir is being added to therapy, but it is associated with an increased incidence of adverse events. We herein report a case of acute pancreatitis developed during treatment with pegylated interferon, ribavirin and boceprevir. Boceprevir was the most likely cause of drug-associated pancreatitis after the most common causes were ruled out, since this adverse event had not occurred when the patient had previously been exposed to pegylated interferon and ribavirin and there was no recurrence of the episode of pancreatitis when these two drugs were reintroduced. Acute pancreatitis is a rare adverse event associated with boceprevir therapy, but a potentially fatal event. Sequential determination of pancreatic enzymes should be considered during hepatitis C treatment with boceprevir.
Keywords Hepatitis C
Protease inhibitor
Side effect
Language English
Date 2014-07-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 18, n. 4, p. 454-456, 2014.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 454-456
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000341171200016
SciELO ID S1413-86702014000400454 (statistics in SciELO)

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