Acute pancreatitis associated with boceprevir: a case report

Acute pancreatitis associated with boceprevir: a case report

Autor Bilar, Juliana Miguel Autor UNIFESP Google Scholar
Carvalho-Filho, Roberto José de Autor UNIFESP Google Scholar
Mota, Carolina Frade Magalhães Girardin Pimentel Autor UNIFESP Google Scholar
Pereira, Patrícia da Silva Fucuta Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Approximately 170 million people are infected with hepatitis C, and the sustained virological response rate to treatment with pegylated interferon and ribavirin is 30-50%. In an attempt to improve the chances of cure, boceprevir is being added to therapy, but it is associated with an increased incidence of adverse events. We herein report a case of acute pancreatitis developed during treatment with pegylated interferon, ribavirin and boceprevir. Boceprevir was the most likely cause of drug-associated pancreatitis after the most common causes were ruled out, since this adverse event had not occurred when the patient had previously been exposed to pegylated interferon and ribavirin and there was no recurrence of the episode of pancreatitis when these two drugs were reintroduced. Acute pancreatitis is a rare adverse event associated with boceprevir therapy, but a potentially fatal event. Sequential determination of pancreatic enzymes should be considered during hepatitis C treatment with boceprevir.
Palavra-chave Hepatitis C
Protease inhibitor
Side effect
Idioma Inglês
Data de publicação 2014-07-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 18, n. 4, p. 454-456, 2014.
ISSN 1413-8670 (Sherpa/Romeo, fator de impacto)
Publicador Brazilian Society of Infectious Diseases
Extensão 454-456
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000341171200016
SciELO S1413-86702014000400454 (estatísticas na SciELO)
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