Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood

Effect of postnatal intermittent hypoxia on locomotor activity and neuronal development in rats tested in early adulthood

Autor Yamada, Karen Yukie Autor UNIFESP Google Scholar
Satake, Susan Autor UNIFESP Google Scholar
Perry, Juliana Cini Autor UNIFESP Google Scholar
Garcia, Karina de Oliveira Autor UNIFESP Google Scholar
D'Almeida, Vânia Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Longo, Beatriz Monteiro Autor UNIFESP Google Scholar
Silva, Regina Claudia Barbosa da Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo The present study evaluated the effects of postnatal intermittent hypoxia on locomotor activity and neuronal cell survival in early adulthood rats. During a critical period of brain development on postnatal day (PD) 7-11, male rat pups were exposed to intermittent hypoxia and randomly assigned to three experimental groups: (1) intermittent hypoxia, (2) normoxia, and (3) control (unhandled). One and a half months later on PD56, a behavioral test was conducted, and cell survival was estimated in the hilus, dental gyrus, and CA1 and CA3 subfields of the hippocampus, nucleus accumbens shell and core, dorsal and ventral striatum, and prefrontal cortex. Our results showed that intermittent hypoxia produced hyperactivity that correlated well with psychomotor agitation observed in patients with schizophrenia. Moreover, post-hypoxic rats exhibited a reduction of the number of neurons in the hilar region of the hippocampus and dorsal striatum, structures that have been neuropathologically associated with schizophrenia.These findings suggest that intermittent hypoxia can modify the pattern of locomotor activity and selectively affect neurons in rats tested in early adulthood.
Palavra-chave hypoxia
neurodevelopment
hyperactivity
cell survival
schizophrenia
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2014-06-01
Publicado em Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 7, n. 2, p. 125-130, 2014.
ISSN 1983-3288 (Sherpa/Romeo)
Publicador Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
Extensão 125-130
Fonte http://dx.doi.org/10.3922/j.psns.2014.02.03
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1983-32882014000200008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8453

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