Frequency of islet cell autoantibodies (IA-2 and GAD) in young Brazilian type 1 diabetes patients

Frequency of islet cell autoantibodies (IA-2 and GAD) in young Brazilian type 1 diabetes patients

Autor Pardini, Victor Cavalcanti Autor UNIFESP Google Scholar
Mourão, D.m. Google Scholar
Nascimento, P.d. Google Scholar
Vívolo, Mariana .Aun Autor UNIFESP Google Scholar
Ferreira, Sandra Roberta Gouvea Autor UNIFESP Google Scholar
Pardini, H. Google Scholar
Instituição Instituto de Patologia Clínica H. Pardini
Hospital Felício Rocho
Universidade Federal de São Paulo (UNIFESP)
Resumo Type 1 diabetes, as an autoimmune disease, presents several islet cell-specific autoantibodies such as islet cell antibody (ICA), anti-insulin, anti-glutamic acid decarboxylase (GAD) and the antibody (Ab) against tyrosine phosphatase (PTP)-like protein known as ICA-512 (IA-2). In order to determine the frequency of the anti-GAD and anti-IA-2 autoantibodies in Brazilian type 1 diabetes patients we studied 35 diabetes mellitus (DM) type 1 patients with recent-onset disease (£12 months) and 37 type 1 diabetes patients with long-duration diabetes (>12 months) who were compared to 12 children with normal fasting glucose. Anti-GAD65 and anti-IA-2 autoantibodies were detected with commercial immunoprecipitation assays. The frequency of positive results in recent-onset DM type 1 patients was 80.0% for GADAb, 62.9% for IA-2Ab and 82.9% for GADAb and/or IA-2Ab. The long-duration type 1 diabetes subjects presented frequencies of 54.1% for GADAb and IA-2Ab, and 67.5% for GAD and/or IA-2 antibodies. The control group showed no positive cases. Anti-GAD and IA-2 assays showed a high frequency of positivity in these Brazilian type 1 diabetes patients, who presented the same prevalence as a Caucasian population.
Palavra-chave type 1 diabetes
autoimmunity
GAD and IA-2 autoantibodies
Idioma Inglês
Data de publicação 1999-10-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 10, p. 1195-1198, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1195-1198
Fonte http://dx.doi.org/10.1590/S0100-879X1999001000003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000083389700003
SciELO S0100-879X1999001000003 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/842

Exibir registro completo




Arquivo

Nome: S0100-879X1999001000003.pdf
Tamanho: 156.6KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta