Do differences exist between chronic hepatitis C genotypes 2 and 3?

Do differences exist between chronic hepatitis C genotypes 2 and 3?

Author Melo, Isaura Cunha de Autor UNIFESP Google Scholar
Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Perez, Renata de Mello Autor UNIFESP Google Scholar
Emori, Christini Takemi Autor UNIFESP Google Scholar
Uehara, Silvia Naomi de Oliveira Autor UNIFESP Google Scholar
Carvalho-Filho, Roberto José de Autor UNIFESP Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Souza e Silva, Ivonete Sandra de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro Departamento de Medicina Interna
Abstract Introduction Six genotypes of the hepatitis C virus (HCV) have been identified thus far, and their distribution is well defined. Genotype 1, which is the most prevalent worldwide, is always compared to genotypes 2 and 3, particularly in terms of treatment response. However, little is known about the differences between genotypes 2 and 3 because these genotypes are analyzed together in most studies. Therefore, the aim of this study was to evaluate differences in the clinical, epidemiological, laboratory, and histological parameters between HCV-2 and HCV-3. Methods Patients with chronic hepatitis C infected with genotypes 2 and 3 were studied retrospectively and compared according to clinical, laboratory, and histological aspects. Hepatitis C virus-ribonucleic acid (HCV-RNA) was analyzed quantitatively by TaqMan® real-time PCR, and the HCV genotype was determined by sequencing the 5′-untranslated region. Results A total of 306 patients with chronic HCV-2 (n=50) and HCV-3 (n = 256) were studied. Subtype 2b (n=17/50) and subtype 3a (n=244/256) were the most prevalent among patients infected with HCV-2 and HCV-3, respectively. The mean age was 47 ± 10 years, and there was a predominance of men in the group studied (61%). Comparative analysis between HCV-2 and HCV-3 showed a younger age (p=0.002), less prevalence of arterial hypertension (p=0.03), higher serum albumin levels (p=0.01), more advanced stage of liver fibrosis (p=0.03), and higher frequency of steatosis in patients with HCV-3 (p=0.001). After multivariate regression analysis, all the variables, except serum albumin, remained as variables associated with HCV-3 in the final model. Conclusions Clinical and histological differences exist between HCV-2 and HVC-3, which suggests the need for separate analyses of these genotypes.
Keywords Hepatitis C
HCV-2
HCV-3
Fibrosis
Language English
Date 2014-04-01
Published in Revista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 47, n. 2, p. 143-148, 2014.
ISSN 0037-8682 (Sherpa/Romeo)
Publisher Sociedade Brasileira de Medicina Tropical - SBMT
Extent 143-148
Origin http://dx.doi.org/10.1590/0037-8682-0269-2013
Access rights Open access Open Access
Type Article
SciELO ID S0037-86822014000200143 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8337

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