Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis

Serum leveis of inflammatory markers in type 2 diabetes patients with chronic periodontitis

Autor Longo, Priscila Larcher Google Scholar
Artese, Hilana Paula Carillo Google Scholar
Rabelo, Mariana de Sousa Google Scholar
Kawamoto, Dione Google Scholar
Foz, Adriana Moura Google Scholar
Romito, Giuseppe Alexandre Google Scholar
Dib, Sergio Atala Autor UNIFESP Google Scholar
Mayer, Marcia Pinto Alves Google Scholar
Instituição University of São Paulo Institute of Biomedical Sciences Department of Microbiology
University of São Paulo School of Dentistry Department of Stomatology
Universidade Federal de São Paulo (UNIFESP)
Resumo Diabetes has been associated with periodontitis, but the mechanisms through which periodontal diseases affect the metabolic control remain unclear.Objective:This study aimed to evaluate serum leveis of inflammatory markers, IL-8, IL-6 and monocyte chemoattractant protein 1 (MCP-1), in type 2 diabetic patients in the presence of chronic periodontitis.Material and Methods:Forty two individuals were enrolled in this study and assigned to one of five groups: diabetes mellitus with inadequate glycemic control and periodontitis (DMI+P, n = 10), diabetes mellitus with adequate glycemic control and periodontitis (DMA+P, n = 10), diabetes mellitus without periodontitis (DM, n = 10), periodontitis without diabetes (P, n=6), and neither diabetes nor periodontitis (H, n = 6). Periodontal clinical examination included visible plaque index (PL), gingival bleeding index (GB), probing depth (PD), attachment level (AL) and bleeding on probing (BP). Glycemic control was evaluated by serum concentration of glycated hemoglobin (HbAlc). Inflammatory serum markers IL-8, IL-6 and (MCP-1) were measured by ELISA. Results: DMI+P and DMA+P groups presented higher PD (p=0.025) and AL (p=0.003) values when compared to the P group. There were no significant differences among groups for IL-6, IL-8 and MCP-1 serum levels. Conclusions:Although periodontitis was more severe in diabetic patients, the serum levels of the investigated inflammatory markers did not differ among the groups.
Assunto Diabetes mellitus
Periodontitis
Cytokines
Inflammation
Idioma Inglês
Data 2014-04-01
Publicado em Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 22, n. 2, p. 103-108, 2014.
ISSN 1678-7757 (Sherpa/Romeo)
Editor Faculdade De Odontologia De Bauru - USP
Extensão 103-108
Fonte http://dx.doi.org/10.1590/1678-775720130540
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1678-77572014000200103 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/8328

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