Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome

Evaluation of conjunctival bacterial flora in patients with Stevens-Johnson Syndrome

Autor Frizon, Luciana Autor UNIFESP Google Scholar
Araujo, Marilia Cavalcante Autor UNIFESP Google Scholar
Andrade, Larissa Autor UNIFESP Google Scholar
Yu, Maria Cecilia Zorat Autor UNIFESP Google Scholar
Wakamatsu, Tais Hitomi Autor UNIFESP Google Scholar
Hofling-Lima, Ana Luisa Autor UNIFESP Google Scholar
Gomes, José Álvaro Pereira Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To determine the conjunctival bacterial flora present in patients with Stevens-Johnson syndrome. METHODS: A prospective study of the conjunctival bacterial flora was performed in 41 eyes of 22 patients with Stevens-Johnson syndrome. The information gathered included the patient's sex and age, the duration of disease, the cause of Stevens-Johnson syndrome, and treatments. Scrapings of the inferior conjunctival fornix were performed in both eyes. Fourteen days before scraping, the patients were asked to interrupt all topical medication and start using 0.5% nonpreserved methylcellulose. The microbiological evaluation included microorganism identification and determination of antibiotic sensitivity. RESULTS: Of 22 patients (41 eyes), 14 (64%) were females, and eight (36%) were males. The mean age was 33.2 years, and the mean duration of disease was 15.6 years. Visual acuity ranged from light perception to 20/25 (1.57 logMar). The treatment received by most patients consisted of tear substitutes, topical antibiotics, and contact lenses. Bacterial identification was positive in 39 eyes (95%) and negative in two eyes (5%). Gram-positive cocci accounted for 55.5% of the microorganisms, whereas gram-positive bacilli and gram-negative bacilli accounted for 19% and 25.5%, respectively. Half of the patients (54%) had multiple bacterial species in their flora, and only one bacterial species was identified in the other half. Resistant bacteria were isolated from four eyes. The antibiotic sensitivity results for the Streptococcus group showed the lowest sensitivity and the highest microbial resistance identified. CONCLUSION: Patients with Stevens-Johnson syndrome have a diverse conjunctival flora that includes many pathogenic species.
Assunto Conjunctival Flora
Microbial Sensitivity Tests
Stevens-Johnson Syndrome
Idioma Inglês
Data 2014-03-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 69, n. 3, p. 168-172, 2014.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
1980-5322 (Sherpa/Romeo, fator de impacto)
Editor Faculdade de Medicina / USP
Extensão 168-172
Fonte http://dx.doi.org/10.6061/clinics/2014(03)04
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000333034000004
SciELO S1807-59322014000300168 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/8259

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