Study of advanced rheumatoid arthritis

Study of advanced rheumatoid arthritis

Autor Carvalho, Carolina Da Silva Google Scholar
Andrade, Luiz Eduardo Coelho Autor UNIFESP Google Scholar
Keusseyan, Silene Peres Autor UNIFESP Google Scholar
Rangel, João Lucas Google Scholar
Ferreira-strixino, Juliana Google Scholar
Martin, Airton Abrahão Google Scholar
Raniero, Leandro José Google Scholar
Instituição Universidade do Vale do Paraíba Instituto de Pesquisa e Desenvolvimento
Universidade Federal de São Paulo (UNIFESP)
Resumo INTRODUCTION: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose rheumatoid arthritis (RA) from human serum. METHODS: The sera of 94 individuals were collected, which included 47 from rheumatic patients and 47 from healthy individuals. The results from PLS analysis were compared to standard clinical trials such as anti-citrullinated peptide antibodies, C- Reactive protein, and Rheumatoid factor. RESULTS: For clinical diagnosis, the anti-citrullinated peptide antibodies of second generation proved to be the most specific to diagnosis rheumatoid arthritis even after long periods of drug therapy. CONCLUSIONS: The qualitative PLS analysis has shown higher values of IgM of RA group, but the difference was very small. The RA patients were under medication, which interfered with the IgM concentration.
Palavra-chave FTIR spectroscopy
Human serum
Rheumatoid arthritis
Partial Least Square
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2014-03-01
Publicado em Revista Brasileira de Engenharia Biomédica. SBEB - Sociedade Brasileira de Engenharia Biomédica, v. 30, n. 1, p. 54-63, 2014.
ISSN 1517-3151 (Sherpa/Romeo)
Publicador SBEB - Sociedade Brasileira de Engenharia Biomédica
Extensão 54-63
Fonte http://dx.doi.org/10.4322/rbeb.2014.004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1517-31512014000100008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8251

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