Cortical morphology changes in women with borderline personality disorder: a multimodal approach

Cortical morphology changes in women with borderline personality disorder: a multimodal approach

Autor Araujo, Thabata B. de Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Sato, João Ricardo Google Scholar
Araújo, Celia M. de Google Scholar
Lisondo, Cláudio M. Google Scholar
Carrete Junior, Henrique Autor UNIFESP Google Scholar
Ancona, Alvaro Google Scholar
Lin, Katia Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Silva, Julieta Freitas Ramalho da Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do ABC Center of Mathematics, Computation and Cognition
Resumo Objective: Borderline personality disorder (BPD) is a devastating condition that causes intense disruption of patients' lives and relationships. Proper understanding of BPD neurobiology could help provide the basis for earlier and effective interventions. As neuroimaging studies of patients with BPD are still scarce, volumetric and geometric features of the cortical structure were assessed to ascertain whether structural cortical alterations are present in BPD patients. Methods: Twenty-five female outpatients with BPD underwent psychiatric evaluation (SCID-I and II) and a 1.5 T magnetic resonance imaging (MRI) brain scan. The control group comprised 25 healthy age-matched females. Images were processed with the FreeSurfer package, which allows analysis of cortical morphology with more detailed descriptions of volumetric and geometric features of cortical structure. Results: Compared with controls, BPD patients exhibited significant cortical abnormalities in the fronto-limbic and paralimbic regions of both hemispheres. Conclusion: Significant morphologic abnormalities were observed in patients with BPD on comparison with a healthy control group through a multimodal approach. This study highlights the involvement of regions associated with mood regulation, impulsivity, and social behavior in BPD patients and presents a new approach for further investigation through a method of structural analysis based on distinct and simultaneous volumetric and geometric parameters.
Assunto Magnetic resonance imaging
borderline personality disorder
mental disorders
Idioma Inglês
Data 2014-03-01
Publicado em Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 36, n. 1, p. 32-38, 2014.
ISSN 1516-4446 (Sherpa/Romeo)
Editor Associação Brasileira de Psiquiatria - ABP
Extensão 32-38
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1516-44462014000100032 (estatísticas na SciELO)

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