The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

Autor Vasconcelos, Luciano de Gois Autor UNIFESP Google Scholar
Jackowski, Andrea Parolin Autor UNIFESP Google Scholar
Oliveira, Maira Okada de Google Scholar
Flor, Yona Mayara Ribeiro Autor UNIFESP Google Scholar
Souza, Altay Alves Lino de Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Brucki, Sonia Maria Dozzi Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions.
Palavra-chave Executive Functions
Alzheimer's Disease
Magnetic Resonance Imaging
Idioma Inglês
Financiador Associacao Fundo de Incentivo a Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico ( CNPq)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Número do financiamento 2008/11282-9
Data de publicação 2014-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 69, n. 1, p. 28-37, 2014.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
1980-5322 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 28-37
Fonte http://dx.doi.org/10.6061/clinics/2014(01)05
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000331250600005
SciELO S1807-59322014000100028 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8210

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