Features of host cell invasion by different infective forms of Trypanosoma cruzi

Features of host cell invasion by different infective forms of Trypanosoma cruzi

Author Mortara, Renato Arruda Autor UNIFESP Google Scholar
Procópio, Daniela O Autor UNIFESP Google Scholar
Barros, Helena C Autor UNIFESP Google Scholar
Verbisck, Newton V Autor UNIFESP Google Scholar
Andreoli, Walter K Autor UNIFESP Google Scholar
Silva, Ricardo Bs Autor UNIFESP Google Scholar
Silva, Solange da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system. We have been interested in several aspects of in vitro interactions of different infective forms of the parasite with cultured mammalian cells. We have observed that not only the classically infective trypomastigotes but also amastigotes, originated from the extracellular differentiation of trypomastigotes, can infect cultured cells. Interestingly, the process of invasion of different parasite infective forms is remarkably distinct and also highly dependent on the host cell type.
Keywords Trypanosoma cruzi
cell invasion
amastigote
trypomastigote
Language English
Date 1999-09-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 94, p. 135-137, 1999.
ISSN 0074-0276 (Sherpa/Romeo)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 135-137
Origin http://dx.doi.org/10.1590/S0074-02761999000700014
Access rights Open access Open Access
Type Article
SciELO ID S0074-02761999000700014 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/817

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