Histological modification in TRAM flap in rats treated with pentoxifylline

Histological modification in TRAM flap in rats treated with pentoxifylline

Autor Lucca, Audrien Furlan de Google Scholar
Brasolin, Adriano Guimarães Google Scholar
Feitosa, Roney Gonçalves Fechine Google Scholar
Enokihara, Milvia Maria Simões e Silva Google Scholar
Gomes, Heitor Francisco de Carvalho Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE: To investigate the blood vessels' concentration in TRAM flap's rat model, in the presence of pentoxifylline.METHODS:32 male, Wistar-EPM rats were divided into two groups. Control group (C): 0.5 ml of saline, intraperitoneally, once a day, for seven days before flap elevation; PTX group (P): pentoxifylline (20mg/kg/day), intraperitoneally, for seven days before flap elevation. After that, they were submitted to a caudal unipedicle TRAM flap. On the fifth postoperative day, percentages of flap necrosis were determined via the paper template method and Tram flap's zone IV skin biopsies were taken for histological analysis.RESULTS:the mean percentage of flap necrosis in group C was 58.7 % and in group P, 31.1 (Wilcoxon test; p = 0.003). Mean capillary vessels number in zone IV's skin in C group was 33.4 and in P group was 71.9 (p=0.008).CONCLUSIONS: Pentoxifylline was effective reducing the necrosis in the caudal unipedicle TRAM flap in the rat as well as increasing the number of capillaries in an ischemic zone (zone IV).
Palavra-chave Pentoxifylline
Surgical flaps
Graft survival
Rats
Idioma Inglês
Data de publicação 2014-01-01
Publicado em Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 34-37, 2014.
ISSN 0102-8650 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extensão 34-37
Fonte http://dx.doi.org/10.1590/S0102-86502014001400007
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000342065300008
SciELO S0102-86502014001400008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8163

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