Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Autor Garcia, Leandro de Borborema Google Scholar
Cunha Junior, Armando da Silva Google Scholar
Fialho, Silvia Ligório Google Scholar
Perez, André Coura Google Scholar
Barros, Bruno Borges de Carvalho Google Scholar
Dorigueto, Ricardo Schaffeln Autor UNIFESP Google Scholar
Testa, Jose Ricardo Gurgel Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Federal University of Minas Gerais Faculty of Pharmacy
Federal University of Minas Gerais
Universidade de São Paulo (USP)
Resumo PURPOSE:To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.METHODS:A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively).RESULTS:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2.CONCLUSION:The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.
Palavra-chave Biopolymers
Inflammation
Ear, Middle
Guinea Pigs
Idioma Inglês
Data de publicação 2014-01-01
Publicado em Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 12-18, 2014.
ISSN 0102-8650 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extensão 12-18
Fonte http://dx.doi.org/10.1590/S0102-86502014001300003
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000342065000004
SciELO S0102-86502014001300004 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8149

Exibir registro completo




Arquivo

Nome: S0102-86502014001300004.pdf
Tamanho: 311.9KB
Formato: PDF
Descrição:
Abrir arquivo

Este item está nas seguintes coleções

Buscar


Navegar

Minha conta