Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Author Garcia, Leandro de Borborema Google Scholar
Cunha Junior, Armando da Silva Google Scholar
Fialho, Silvia Ligório Google Scholar
Perez, André Coura Google Scholar
Barros, Bruno Borges de Carvalho Google Scholar
Dorigueto, Ricardo Schaffeln Autor UNIFESP Google Scholar
Testa, Jose Ricardo Gurgel Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Federal University of Minas Gerais Faculty of Pharmacy
Federal University of Minas Gerais
Universidade de São Paulo (USP)
Abstract PURPOSE:To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant.METHODS:A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively).RESULTS:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2.CONCLUSION:The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.
Keywords Biopolymers
Inflammation
Ear, Middle
Guinea Pigs
Language English
Date 2014-01-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 12-18, 2014.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 12-18
Origin http://dx.doi.org/10.1590/S0102-86502014001300003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000342065000004
SciELO ID S0102-86502014001300004 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8149

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