Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

Evaluation of antimicrobial and antitumoral activity of Garcinia mangostana L. (mangosteen) grown in Southeast Brazil

Autor Cunha, Bruna Lais Almeida Google Scholar
França, Jerônimo Pereira de Autor UNIFESP Google Scholar
Moraes, Andrea Aparecida Fátima Souza Autor UNIFESP Google Scholar
Chaves, Alba Lucilvânia Fonseca Google Scholar
Gaiba, Silvana Google Scholar
Fontana, Renato Google Scholar
Sacramento, Celio Kersul do Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
França, Lucimar Pereira de Google Scholar
Instituição Universidade Estadual de Santa Cruz Department of Biological Sciences
Universidade Estadual de Santa Cruz Departament of Agricultural and Environmental Sciences
Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE:To characterize the anatomy of the fruit and leaf and the presence of phytocompounds. To evaluate the antitumor and antimicrobial activity of ethanolic extract of Garcinia mangostana L. (mangosteen) cultivated in southeastern Brazil.METHODS:Anatomical characterization and histochemical reactions were performed for structural identification and the presence of phytocompounds. Preparation of ethanolic extract of the fruit, leaf and resin of mangosteen. Culture B16-F10 melanoma cells for treatment with mangosteen ethanolic extract to determine cell viability by MTT and genotoxic effect by comet assay. Evaluation by antimicrobial activity against Staphylococcus aureus and Escherichia coli by agar diffusion test and by determination of Minimum Inhibitory Concentration (MIC).RESULTS:Our results showed many secretory canals in resin fruit and leaf; identifying lipids, starch, lignin and phenolic compounds. The leaf extract induced genotoxicity and apoptosis in B16-F10 cells, since the fragmentation of DNA in the comet assay. The ethanolic extract of mangosteen obtained in the resin, leaf and fruit showed antimicrobial activity against Staphylococcus aureus and Escherichia coli with a MIC at 0.1 mg/mL.CONCLUSION: In conclusion, we have demonstrated both antimicrobial and antitumor activity of ethanol extract of mangosteen emphasizing its therapeutic potential in infectious diseases and in cancer, such as melanoma.
Assunto Garcinia mangostana L.
Drug Screening Assays, Antitumor
Anti-Infective Agents
Antimicrobial
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Bahia Research Foundation (FAPESB)
Data 2014-01-01
Publicado em Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, p. 21-28, 2014.
ISSN 0102-8650 (Sherpa/Romeo, fator de impacto)
Editor Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extensão 21-28
Fonte http://dx.doi.org/10.1590/S0102-86502014001400005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000342065300006
SciELO S0102-86502014001400006 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/8139

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