Scaffolds of calcium phosphate cement containing chitosan and gelatin

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Author Renó, C. O. Autor UNIFESP Google Scholar
Lima, B.f.a.s. Autor UNIFESP Google Scholar
Trichês, Eliandra de Sousa Autor UNIFESP Google Scholar
Bertran, C.a. Google Scholar
Motisuke, Mariana Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Abstract Calcium phosphate cements (CPCs) have potential to be used on repairing damaged bones due to their moldability, bioactivity and bioresorbability. These materials combine calcium orthophosphate powders with a liquid leading to a paste that hardens spontaneously at low temperatures. Hence, CPCs could be applied as scaffolds to support cell/tissue growth. This paper studies CPC scaffolds processing by foaming cement's liquid phase in which was added gelatin and chitosan. The former acted to increase the foam stability while the ladder acted as a foaming agent. Moreover, these polymers would enhance scaffold's biological properties by controlling material's total porosity and in vivo resorption. The method proposed led to scaffolds with 58.71% porosity with sizes ranging from 160 to 760 µm and compressive strength of 0.70MPa. After foaming, pores' size, distribution and interconnectivity changed significantly leading to a material that could be applied on bone regeneration since it would allow nutrient's transport, cell attachment and an increase in material degradation rate.
Keywords scaffolds
calcium phosphate cements
gelatin
chitosan
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2011/09240-9
Date 2013-12-01
Published in Materials Research. ABM, ABC, ABPol, v. 16, n. 6, p. 1362-1365, 2013.
ISSN 1516-1439 (Sherpa/Romeo, impact factor)
Publisher ABM, ABC, ABPol
Extent 1362-1365
Origin http://dx.doi.org/10.1590/S1516-14392013005000124
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000328910600021
SciELO ID S1516-14392013000600021 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8096

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