Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study

Is disorganized schizophrenia a predictor of treatment resistance? Evidence from an observational study

Autor Ortiz, Bruno Bertolucci Google Scholar
Araujo Filho, Gerardo Maria de Autor UNIFESP Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Medeiros, Daiane Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Associação Paulista para o Desenvolvimento da Medicina (SPDM) Hospital das Clínicas Luzia de Pinho Melo Department of Psychiatry
São José do Rio Preto Medical School Department of Psychiatry and Medical Psychology
Resumo Objective: To investigate whether inpatients with disorganized schizophrenia are more resistant to treatment. Method: Eighty-five inpatients were assessed at admission and at discharge for schizophrenia subtype, symptom severity, and treatment resistance criteria. Results: Disorganized patients were significantly more treatment-resistant than paranoid patients (60%, p = 0.001), and presented worse scores on the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression Scale (CGI-S), and the Global Assessment of Functioning Scale (GAF) (p < 0.001). Although the difference was not significant, 80% of treatment-resistant patients with disorganized schizophrenia responded to clozapine. Conclusion: Patients with the disorganized subtype of schizophrenia should benefit from clozapine as a second-line agent.
Palavra-chave Clozapine response
disorganized schizophrenia
treatment-resistant schizophrenia
subtypes of schizophrenia
clinical predictors
Idioma Inglês
Data de publicação 2013-12-01
Publicado em Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 4, p. 432-434, 2013.
ISSN 1516-4446 (Sherpa/Romeo)
Publicador Associação Brasileira de Psiquiatria - ABP
Extensão 432-434
Fonte http://dx.doi.org/10.1590/1516-4446-2013-1190
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1516-44462013000400432 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8085

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