pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers

pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers

Autor Lima, Thamires Marques de Google Scholar
Kazama, Cristiane Mayumi Google Scholar
Koczulla, Andreas Rembert Google Scholar
Hiemstra, Pieter S. Google Scholar
Macchione, Mariangela Google Scholar
Fernandes, Ana Luisa Godoy Autor UNIFESP Google Scholar
Santos, Ubiratan de Paula Google Scholar
Bueno-Garcia, Maria Lucia Google Scholar
Zanetta, Dirce Maria Google Scholar
Andre, Carmen Diva Saldiva Google Scholar
Saldiva, Paulo Hilário Nascimento Google Scholar
Nakagawa, Naomi Kondo Google Scholar
Instituição Universidade de São Paulo (USP)
Philipps University
Leiden University Medical Center
Universidade Federal de São Paulo (UNIFESP)
Instituto do Coração
Resumo OBJECTIVE: To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. METHODS: A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). RESULTS: Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. CONCLUSION: The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.
Palavra-chave Exhaled Breath Condensate
Nasal Lavage Fluid
Air Pollution
Airway Inflammation
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Número do financiamento FAPESP: 07/51605-9
FAPESP: 09/50056-7
CNPq: 555.223/06-0
Data de publicação 2013-12-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 68, n. 12, p. 1488-1494, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
1980-5322 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 1488-1494
Fonte http://dx.doi.org/10.6061/clinics/2013(12)03
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000329985900003
SciELO S1807-59322013001201488 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/8060

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