Assessing the diversity of the virulence potential of Escherichia coli isolated from bacteremia in São Paulo, Brazil

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dc.contributor.author Santos, A.c.m.
dc.contributor.author Zidko, A.c.m.
dc.contributor.author Pignatari, Antonio Carlos Campos [UNIFESP]
dc.contributor.author Silva, Rosa Maria [UNIFESP]
dc.date.accessioned 2015-06-14T13:45:40Z
dc.date.available 2015-06-14T13:45:40Z
dc.date.issued 2013-11-01
dc.identifier http://dx.doi.org/10.1590/1414-431X20133184
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 46, n. 11, p. 968-973, 2013.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/8005
dc.description.abstract Most of the knowledge of the virulence determinants of extraintestinal pathogenic Escherichia coli (ExPEC) comes from studies with human strains causing urinary tract infections and neonatal meningitis and animal strains causing avian colibacillosis. In this research, we analyzed the phylogenetic background, the presence of 20 ExPEC virulence factors, and the intrinsic virulence potential of 74 E. coli strains isolated in São Paulo, Brazil, from 74 hospitalized patients (43 males and 31 females) with unknown-source bacteremia. Unlike other places in the world, the bacteremic strains originated equally from phylogroups B2 (35%) and D (30%). A great variability in the profiles of virulence factors was noted in this survey. Nevertheless, 61% of the strains were classified as ExPEC, meaning that they possessed intrinsic virulent potential. Accordingly, these strains presented high virulence factor scores (average of 8.7), and were positively associated with 12 of 17 virulence factors detected. On the contrary, the non-ExPEC strains, isolated from 39% of the patients, presented a generally low virulence capacity (medium virulence factor score of 3.1), and were positively associated with only the colicin cvaC gene. These results show the importance of discriminating E. coli isolates that possess characteristics of true pathogens from those that may be merely opportunistic in order to better understand the virulence mechanisms involved in extraintestinal E. coli infections. Such knowledge is essential for epidemiological purposes as well as for development of control measures aimed to minimize the incidence of these life-threatening and costly infections. en
dc.format.extent 968-973
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject Bacteremia en
dc.subject Extraintestinal pathogenic Escherichia coli en
dc.subject Virulence factors en
dc.subject Intrinsic virulence potential en
dc.subject Phylogenetic background en
dc.title Assessing the diversity of the virulence potential of Escherichia coli isolated from bacteremia in São Paulo, Brazil en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Imunologia e Parasitologia Departamento de Microbiologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Laboratorio Especial de Microbiologia Clinica
dc.description.affiliationUnifesp UNIFESP, Imunologia e Parasitologia Depto. de Microbiologia
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina Laboratorio Especial de Microbiologia Clinica
dc.identifier.file S0100-879X2013001100968.pdf
dc.identifier.scielo S0100-879X2013001100968
dc.identifier.doi 10.1590/1414-431X20133184
dc.description.source SciELO



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