Experimental model of cutaneous radiation injury in rabbits

Experimental model of cutaneous radiation injury in rabbits

Author Meirelles, Rafael Panisi de Campos Autor UNIFESP Google Scholar
Hochman, Bernardo Autor UNIFESP Google Scholar
Helene Junior, Americo Google Scholar
Lellis, Rute Google Scholar
Fraga, Murillo Francisco Pires Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Department of Surgery Division of Plastic Surgery
Faculty of Medical Sciences of Santa Casa of São Paulo Department of Surgery Division of Plastic Surgery
Faculty of Medical Sciences of Santa Casa of São Paulo Division of Plastic Surgery
Abstract PURPOSE: To describe an experimental model of cutaneous radiation injury in rabbits. METHODS: On this study eight six-month-old New Zealand male rabbits, with an average weight of 2.5kg were used. They were distributed in four groups (n=2 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 2000, 3000 and 4500 cGy, respectively. Photographic analysis and histopathological evaluation of the irradiated areas were carried out. RESULTS: After 30 days, the animals from the control group had all their hair grown. In spite of that, the animals from group 2000 cGy had a 60-day alopecia and from group 3000 cGy, a 90-day alopecia. After the 30th day, the 3000cGy group demonstrated 90-day cutaneous radiation injuries, graded 3 and 4. One of the animals from group 4500 cGy died on the 7th day with visceral necrosis. The other from the same group had total skin necrosis. A progressive reduction of glands and blood vessels count and an increase on collagen deposition was observed. CONCLUSION: The proposed experimental model is reproductable. This study suggests that the dosage 4500cGy is excessive and the 3000 cGy is the most effective for this experimental model of cutaneous radiation injury in rabbits.
Keywords Radiation Injuries
Radiotherapy Dosage
Models, Animal
Rabbits
Language English
Date 2013-11-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 11, p. 751-755, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 751-755
Origin http://dx.doi.org/10.1590/S0102-86502013001100001
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000328649600001
SciELO ID S0102-86502013001100001 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/8001

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