Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Effect of hyperbaric oxygen therapy combined with autologous platelet concentrate applied in rabbit fibula fraction healing

Autor Neves, Paulo Cesar Fagundes Google Scholar
Abib, Simone de Campos Vieira Autor UNIFESP Google Scholar
Neves, Rogerio Fagundes Autor UNIFESP Google Scholar
Pircchio, Oronzo Google Scholar
Saad, Karen Ruggeri Autor UNIFESP Google Scholar
Saad, Paulo Fernandes Autor UNIFESP Google Scholar
Simoes, Ricardo Santos Autor UNIFESP Google Scholar
Moreira, Marcia Bento Google Scholar
Laurino, Cristiano Frota de Souza Google Scholar
Instituição Universidade Federal do Vale do Sao Francisco Colegiado de Medicina
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Vale do Sao Francisco Colegiado de Medicina Veterinaria
Sociedade Brasileira de Traumatologia Esportiva e Artroscopia
Resumo OBJECTIVES: The purpose is to study the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing the fibula bone of rabbits after induced fractures. METHODS: A total of 128 male New Zealand albino rabbits, between 6-8 months old, were subjected to a total osteotomy of the proximal portion of the right fibula. After surgery, the animals were divided into four groups (n = 32 each): control group, in which animals were subjected to osteotomy; autologous platelet concentrate group, in which animals were subjected to osteotomy and autologous platelet concentrate applied at the fracture site; hyperbaric oxygen group, in which animals were subjected to osteotomy and 9 consecutive daily hyperbaric oxygen therapy sessions; and autologous platelet concentrate and hyperbaric oxygen group, in which animals were subjected to osteotomy, autologous platelet concentrate applied at the fracture site, and 9 consecutive daily hyperbaric oxygen therapy sessions. Each group was divided into 4 subgroups according to a pre-determined euthanasia time points: 2, 4, 6, and 8 weeks postoperative. After euthanasia at a specific time point, the fibula containing the osseous callus was prepared histologically and stained with hematoxylin and eosin or picrosirius red. RESULTS: Autologous platelet concentrates and hyperbaric oxygen therapy, applied together or separately, increased the rate of bone healing compared with the control group. CONCLUSION: Hyperbaric oxygen therapy and autologous platelet concentrate combined increased the rate of bone healing in this experimental model.
Palavra-chave Hyperbaric Oxygenation
Platelet-rich Plasma
Fibula, Fracture Consolidation
Idioma Inglês
Financiador Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Número do financiamento 104698
Data de publicação 2013-09-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 68, n. 9, p. 1239-1246, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
1980-5322 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 1239-1246
Fonte http://dx.doi.org/10.6061/clinics/2013(09)11
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000326016600011
SciELO S1807-59322013000901239 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7947

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