Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations

Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations

Autor Murad, Neif Autor UNIFESP Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (smax) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 ± 14 mmHg) than control (C; N = 8) animals (155 ± 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 ± 11 mmHg). In contrast, the estimated smax for C (145 ± 26 kdynes/cm2) and R (133 ± 17 kdynes/cm2) was higher than for H (110 ± 13 kdynes/cm2). According to Laplace's law, the opposite results of DPmax and smax may depend on the increased mass/volume left ventricle ratio of the hypertrophied hearts, which favored pressure generation. These results clearly show that DPmax should be used with caution to analyze systolic function.
Palavra-chave contractile function
developed pressure
wall stress
cardiac hypertrophy
Laplace's law
Idioma Inglês
Data de publicação 1999-06-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 6, p. 773-776, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 773-776
Fonte http://dx.doi.org/10.1590/S0100-879X1999000600014
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000080896000014
SciELO S0100-879X1999000600014 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/790

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