Heparan sulfate and cell division

Heparan sulfate and cell division

Autor Porcionatto, Marimélia Aparecida Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Heparan sulfate is a component of vertebrate and invertebrate tissues which appears during the cytodifferentiation stage of embryonic development. Its structure varies according to the tissue and species of origin and is modified during neoplastic transformation. Several lines of experimental evidence suggest that heparan sulfate plays a role in cellular recognition, cellular adhesion and growth control. Heparan sulfate can participate in the process of cell division in two distinct ways, either as a positive or negative modulator of cellular proliferation, or as a response to a mitogenic stimulus.
Palavra-chave heparan sulfate
glycosaminoglycan
proteoglycan
cell division
cell cycle
growth factors
Idioma Inglês
Data de publicação 1999-05-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 5, p. 539-544, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 539-544
Fonte http://dx.doi.org/10.1590/S0100-879X1999000500006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000080489600006
SciELO S0100-879X1999000500006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/776

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